The axon initial segment (AIS)

We are particularly interested in the dynamic protein interactions happening at this remarkable structure of the neuron. 

The CRISPR-genome engineering

We use HiUGE (Gao, et al, 2019) to rapidly tag and manipulate endogenous proteins in vitro and in vivo for discovery-driven research of protein functions. 

The AI "Crystal Ball"

We use AI-driven computational structural biology to predict and model protein interactions to scale. A crystal ball for candidate screening and prioritization! 

The Microelectrode Array (MEA)

We use MEA for high-content, high-throughput neural phenotyping - that is, electrophysiology on a 96-well plate! 

The "happy accidents"

Science is not fun without "happy accidents". Shown here is a gel that was left out for some time. It crystalized.